Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator

Abstract. The signal of magnetic resonance imaging (MRI) can be enhanced by several orders magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already in clinical trials, the parahydrogen (pH2)-based hyperpolarization approaches are less cost-intensive, scalable, and offer high throughput. However, pH2 generator necessary. Available commercial generators relatively expensive (EUR 10 000–150 000). To facilitate spread pH2-based studies, here we provide blueprints 3D models as open-source for low-cost <3000) 50-bar liquid-nitrogen-cooled generator.